Preimplantation Genetic Testing
Preimplantation Genetic Testing is extremely important for couples who are at high risk of passing genetic diseases on to their children, as the treatment enables the detection of various abnormalities in fertilized embryos before they are implanted into the uterus. In other words, PGT prevents embryos carrying genetic or chromosomal disorders from being used in an attempt to start a family.
The PGT technique, which is currently fundamental in some IVF/ICSI treatments, takes place in 3 stages.
Preliminary analysis of the parents’ genetic material. Tests are carried out using DNA samples collected from the genetic material that will be used by the couple to identify possible combinations that may cause genetic diseases. The goal is to provide PGT with information so it can be more accurate, since specialists will know what to expect;
Obtaining the embryos to be tested. This stage is an integral part of the IVF/ICSI process. After ovarian stimulation, egg retrieval, fertilization, and embryo development to the cleavage stage (Day 3) or blastocyst stage (Day 5), they will be ready for stage 3;
Embryo biopsy. Cells are removed from the embryo and then sent for analysis. These extracted cells do not interfere in any way with the embryo’s natural development. After the biopsy, the embryos are cryopreserved while awaiting the report. Following the genetic diagnoses, healthy embryos are selected and implanted.
It is a comprehensive and detailed procedure. All genetic diseases and chromosomal abnormalities (such as trisomy 21, for example) can be detected through PGT with high precision and effectiveness.
PGT is recommended for people with a uterine age over 35 years, patients with a history of multiple miscarriages, patients who may pass on genetic diseases and chromosomal abnormalities, and in cases of repeated implantation failures during the IVF/ICSI process.
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